A visual and quantitative method of dynamically measuring microcirculatory blood flow in a tissue or organ in real time was developed using laser speckle contrast imaging technology. It has been used in numerous microcirculation detection domains because of its benefits of in vivo detection, real-time imaging, and ease of operation.Most animal models of chronic cerebral hypoperfusion involve decreasing blood flow to the brain from bilateral common carotid arteries, which can lead to a protracted deficit in cerebral blood supply. By monitoring and analyzing cortical cerebral blood flow, collateral circulation opening, and neurovascular coupling responses, laser speckle contrast imaging technology assesses the efficacy of modeling and the therapeutic effect of interventions in animal models of chronic cerebral hypoperfusion. This article summarizes the benefits and drawbacks of laser speckle contrast imaging in an animal model of chronic cerebral hypoperfusion to promote novel approaches to clinical care and academic study.