Advances in the mechanism⁃of⁃action of circRNA in Parkinson’s disease

doi:10. 3969 / j.issn.1671-7856. 2024. 02. 020

Home > Archive>Volume 34, Issue 2, 2024 >161-166. DOI:10. 3969 / j.issn.1671-7856. 2024. 02. 020

Advances in the mechanism⁃of⁃action of circRNA in Parkinson’s disease
DOI:
                        10. 3969 / j.issn.1671-7856. 2024. 02. 020
                    
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Author:
                        LIU Juan1 LIU Juan
1. Faculty of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China.
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LI Yanjie1,2 LI Yanjie
1. Faculty of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Department of Rehabilitation, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou 450046)
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QIN Hewei1,2 QIN Hewei
1. Faculty of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Department of Rehabilitation, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou 450046)
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MA Luyao1 MA Luyao
1. Faculty of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China.
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ZHAO Nannan1 ZHAO Nannan
1. Faculty of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China.
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XU Zhenhua1 XU Zhenhua
1. Faculty of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China.
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Affiliation:1. Faculty of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Department of Rehabilitation, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou 450046)
Clc Number:R-33
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Abstract:

PD is a neurodegenerative disease characterized by degenerative death of dopaminergic neurons in the substantia nigra, exhibiting a range of motor and non-motor symptoms with serious effects on quality of life. circRNA is a covalently closed-loop non-coding RNA that plays a major role in PD progression. This article reviews the involvement of circRNA in oxidative stress, regulation of transcription, neuroinflammation, autophagy, and α-synuclein.

Key words:Parkinson’s disease; circRNA; oxidative stress; neuroinflammation; biomarkers

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Received:April 24,2023
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Online: May 07,2024
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