Experimental study on the health hazards of respiratory exposure to brake pad particles and their main component antimony sulfide in mice

doi:10.3969/j.issn.1671-7856.2024.03.002

Home > Archive>Volume 34, Issue 3, 2024 >10-17. DOI:10.3969/j.issn.1671-7856.2024.03.002

Experimental study on the health hazards of respiratory exposure to brake pad particles and their main component antimony sulfide in mice
DOI:
                        10.3969/j.issn.1671-7856.2024.03.002
                    
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Author:
                        LI YanhongLI Yanhong
Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences; Center of Comparative Medicine, Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Disease Animal Models,State Administration of Traditional Chinese Medicine, Beijing 100021, China
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XIU JinghuiXIU Jinghui
Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences; Center of Comparative Medicine, Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Disease Animal Models,State Administration of Traditional Chinese Medicine, Beijing 100021, China
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ZHOU LiZHOU Li
Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences; Center of Comparative Medicine, Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Disease Animal Models,State Administration of Traditional Chinese Medicine, Beijing 100021, China
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GUO JianguoGUO Jianguo
Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences; Center of Comparative Medicine, Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Disease Animal Models,State Administration of Traditional Chinese Medicine, Beijing 100021, China
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Affiliation:Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences; Center of Comparative Medicine, Peking Union Medical College; NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Disease Animal Models,State Administration of Traditional Chinese Medicine, Beijing 100021, China
Clc Number:R-33
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Abstract:

Objective To study the potential harmful effects of brake-pad sourced particles. Methods Grind the brake pad particles or antimony sulfide particles. Mice were exposed brake pad or antimony sulfide particles by tracheal perfusion for 1 month. We observed pathological changes to the lungs, heart, and liver, and analyzed changes in peripheral blood macrophages and regulatory T cells (Tregs) via flow cytometry. Results After exposure, the deposition of foreign substances in the alveolar wall of mice was seen, with the obvious infiltration of inflammatory cells around blood vessels,which worsened with increasing particle concentration. Pathological changes, such as vascular inflammation and microthrombosis in the heart and hepatocyte swelling in the liver, were observed. Treg cells in peripheral blood decreased and macrophages increased in the antimony sulfide group and low-dose brake pad particles group, while the proportion of M2-type macrophages decreased, in the antimony sulfide group and low-dose brake pad particle group. Conclusions Exposure to brake pad particles and their component antimony sulfide has varying degrees of toxic effects on the lung,heart, and liver of mice and has an impact on the immune system, indicating the potential health hazards of brake-padderived air pollution.

Key words:brake pad particles; antimony sulfide; PM2. 5 ; inflammation; immune response

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Received:September 08,2023
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Online: May 29,2024
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