Research progress on the regulation of glutamate in traditional Chinese medicine for treatment of depression

doi:10.3969/j.issn.1671-7856.2024.03.017

Home > Archive>Volume 34, Issue 3, 2024 >133-141. DOI:10.3969/j.issn.1671-7856.2024.03.017

Research progress on the regulation of glutamate in traditional Chinese medicine for treatment of depression
DOI:
                        10.3969/j.issn.1671-7856.2024.03.017
                    
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                        LI Chao1LI Chao
1. College of Traditional Chinese Medicine of North China University of Science and Technology, Tangshan 063210, China
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LI Jian1LI Jian
1. College of Traditional Chinese Medicine of North China University of Science and Technology, Tangshan 063210, China
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GAO Zhenan1GAO Zhenan
1. College of Traditional Chinese Medicine of North China University of Science and Technology, Tangshan 063210, China
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SHEN Mingyu1SHEN Mingyu
1. College of Traditional Chinese Medicine of North China University of Science and Technology, Tangshan 063210, China
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PU Jingjing2PU Jingjing
2. Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications, Tangshan 063210
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WANG Meng1WANG Meng
1. College of Traditional Chinese Medicine of North China University of Science and Technology, Tangshan 063210, China
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Affiliation:1. College of Traditional Chinese Medicine of North China University of Science and Technology, Tangshan 063210, China.2. Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications, Tangshan 063210
Clc Number:R-33
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Abstract:

Glutamate is a major excitatory neurotransmitter in the central nervous system and a potential neurotoxin. During the development of depression, the glutamate concentration increases in the hippocampus. When glutamate accumulates, it causes serious damage to neurons and brain tissue, aggravating the depressive state. Therefore,glutamate accumulation may be a major mechanism of depression development. Astrocytes, glutamate transporters, and glutamate receptors play important regulatory roles in the glutamate concentration. This article reviews the mechanism-ofaction of traditional Chinese medicine on depression by regulating astrocytes, glutamate transporters, and glutamate receptors, and provides new ideas to explore treatment of depression by traditional Chinese medicine.

Key words:traditional Chinese medicine; depression; glutamic acid; research progress

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Received:June 20,2023
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Online: May 29,2024
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