Application and research prospects of experimental animal models of chronic stress
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1. Institute of Microcirculation & Basic Medical College, Hebei North University, Zhangjiakou 075000, China.2. Hebei Key Laboratory of Acute and Severe Disease Pathogenesis and Intervention, Zhangjiakou, 075000.3. Basic Medical College, Hebei Medical University, Shijiazhuang 050017

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R-33

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    Abstract:

    The effect and mechanism of chronic stress on psychosomatic diseases are important topics in stress research. The establishment of animal models to simulate human chronic stress is of great significance to investigations of stress responses, the pathogenesis of related diseases, clinical treatment, and drug development. In this paper, animal models of chronic stress commonly used in China and abroad are reviewed; the classification of stressors, animal selection,model construction, pathological manifestations, and evaluation indexes are summarized; and the advantages and disadvantages and application of various models are discussed. The paper provides a reference for the study and selection of models of chronic stress response.

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History
  • Received:October 07,2023
  • Online: June 20,2024
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