The ezrin, radixin, moesin (ERM) protein family plays a pivotal role in cell morphology, migration,and signal transduction. Ezrin, as a prominent member of this family, is highly involved in these processes. Ezrin phosphorylation is particularly crucial, by regulating the interaction between ezrin and the actin cytoskeleton. This interaction is a key mediator of cytotoxicity in host cells infected with Helicobacter pylori, significantly impacting cell morphology. In this review, we comprehensively summarize the multifaceted role of ezrin protein in H. pylori-induced nodular gastritis. We consider the relationships between ezrin ’ s structure, function, signaling pathways, and phosphorylation in the context of nodular gastritis. Moreover, this review highlights the role of ezrin protein as a potential therapeutic target, offering novel insights for the prevention and treatment of nodular gastritis.