Effects of ezrin protein on Helicobacter pylori-induced nodular gastritis

doi:10.3969/j.issn.1671-7856.2024.07.017

Home > Archive>Volume 34, Issue 7, 2024 >150-156. DOI:10.3969/j.issn.1671-7856.2024.07.017

Effects of ezrin protein on Helicobacter pylori-induced nodular gastritis
DOI:
                        10.3969/j.issn.1671-7856.2024.07.017
                    
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Author:
                        WANG Peng1,2WANG Peng
1. Department of Medical Laboratory, the Second Affiliated Hospital of Baotou Medical College, Baotou 104030, China.2. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand
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ZHU Hongwei2ZHU Hongwei
2. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand
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JIANG Shuyuan2JIANG Shuyuan
2. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand
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LIU Xiaolei2LIU Xiaolei
2. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand
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GAO Bing2GAO Bing
2. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand
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SHAO Guo2,3,4SHAO Guo
2. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand. 3. Center for Translational Medicine, the Third People’s Hospital of Longgang District, Shenzhen 518100. 4. Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou 014060
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Affiliation:1. Department of Medical Laboratory, the Second Affiliated Hospital of Baotou Medical College, Baotou 104030, China.2. Department of Public Health, International College, Krirk University, Bangkok 10220, Thailand. 3. Center for Translational Medicine, the Third People’s Hospital of Longgang District, Shenzhen 518100. 4. Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou 014060
Clc Number:R-33
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Abstract:

The ezrin, radixin, moesin (ERM) protein family plays a pivotal role in cell morphology, migration,and signal transduction. Ezrin, as a prominent member of this family, is highly involved in these processes. Ezrin phosphorylation is particularly crucial, by regulating the interaction between ezrin and the actin cytoskeleton. This interaction is a key mediator of cytotoxicity in host cells infected with Helicobacter pylori, significantly impacting cell morphology. In this review, we comprehensively summarize the multifaceted role of ezrin protein in H. pylori-induced nodular gastritis. We consider the relationships between ezrin ’ s structure, function, signaling pathways, and phosphorylation in the context of nodular gastritis. Moreover, this review highlights the role of ezrin protein as a potential therapeutic target, offering novel insights for the prevention and treatment of nodular gastritis.

Key words:Helicobacter pylori; nodular gastritis; ERM proteins; ezrin

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Received:January 11,2024
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Online: August 19,2024
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