Analysis of blood physiological and biochemical indicators of spontaneous type 2 diabetes in inbred SHANXI MU Chinese hamsters
Author:
Affiliation:

1. Laboratory Animal Center of Shanxi Medical University, Taiyuan 030001, China.2. Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human Diseases, Taiyuan 030001

Clc Number:

R-33

  • Article
  • | |
  • Metrics
  • |
  • Reference
  • | |
  • Cited by
  • | |
  • Comments
    Abstract:

    Objective To determine the blood physiological and biochemical indexes in the inbred SHANXI MU strain of spontaneous type 2 diabetes (T2DM) Chinese hamsters. Methods Chinese hamsters with spontaneously developed T2DM and normal hamsters (n=10 hamsters per group), aged 12 months, were selected for the study. Fasting blood samples were collected and 15 physiological parameters and 16 biochemical indicators were analyzed using a Sysmex XT automated hematology analyzer and Hitachi fully automatic biochemical analyzer. Results The white cell count, red cell count, platelet count, hemoglobin level, alanine transaminase, aspartate transaminase, glutamate, total cholesterol, triglycerides, and uric acid all differed significantly between the diabetic and control groups (P<0.05). Conclusions The change of blood physiological and biochemical indexes in the Chinese hamster spontaneous T2DM model were in line with the trend in human T2DM incidence, thus providing basic data for the application of this model.

    Reference
    Related
    Cited by
Get Citation
Share
Article Metrics
  • Abstract:120
  • PDF: 466
  • HTML: 0
  • Cited by: 0
History
  • Received:April 17,2024
  • Online: October 30,2024
Article QR Code