Research progress in diarrhea animal models and drug therapies

doi:10.3969/j.issn.1671-7856.2024.09.012

Home > Archive>Volume 34, Issue 9, 2024 >94-107. DOI:10.3969/j.issn.1671-7856.2024.09.012

Research progress in diarrhea animal models and drug therapies
DOI:
                        10.3969/j.issn.1671-7856.2024.09.012
                    
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                        SHI Yucun1,2SHI Yucun
1. School of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.2. Longyao Industry Innovation Research Institute, Lanzhou 730000
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DONG Xiaoli1,3DONG Xiaoli
1. School of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China. 3. Collaborative Innovation Center for Northwest Chinese and Tibetan Medicine, Lanzhou 730000
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HOU Xiaoying1,2HOU Xiaoying
1. School of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.2. Longyao Industry Innovation Research Institute, Lanzhou 730000
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YIN Kai1,2YIN Kai
1. School of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.2. Longyao Industry Innovation Research Institute, Lanzhou 730000
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GAO Fan1,4GAO Fan
1. School of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China. 4. Gansu Provincial Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine, Lanzhou 730000
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WU Guotai2,3,4WU Guotai
2. Longyao Industry Innovation Research Institute, Lanzhou 730000. 3. Collaborative Innovation Center for Northwest Chinese and Tibetan Medicine, Lanzhou 730000. 4. Gansu Provincial Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine, Lanzhou 730000
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Affiliation:1. School of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.2. Longyao Industry Innovation Research Institute, Lanzhou 730000. 3. Collaborative Innovation Center for Northwest Chinese and Tibetan Medicine, Lanzhou 730000. 4. Gansu Provincial Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine, Lanzhou 730000
Clc Number:R-33
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Abstract:

Diarrhea is a common and frequent disease in clinical practice. Many factors cause diarrhea, and numerous research method with animal models of diarrhea have been explored. Despite this, drugs for the treatment of diarrhea in clinical practice are limited, and some existing drugs are only suitable for diarrhea caused by a single factor. Therefore, the construction and selection of appropriate animal models of diarrhea are not only important for in-depth studies of the pathogenesis, but are also effective means for the clinical screening and evaluation of drugs for comprehensively preventing and treating diarrhea. This article reviews the literature on the establishment and evaluation of animal models of functional, bacterial, viral, and symptomatic diarrhea, as well as progress of therapeutic drug research, to provide a reference for animal experimental research into the prevention and treatment of diarrhea.

Key words:diarrhea; animal model; drug therapy; research progress

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Received:March 15,2024
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Online: October 30,2024
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