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Home > Archive>Volume 34, Issue 9, 2024 >127-136. DOI:10.3969/j.issn.1671-7856.2024.09.015
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Research progress on the AMPK signaling pathway-based pharmacological mechanism of traditional Chinese medicine in the treatment of cerebral ischemia-reperfusion injury
Author:
Affiliation:

1. Department of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China. 2. Henan University of Traditional Chinese Medicine First Clinical Medical College, Zhengzhou 450046

Clc Number:

R-33

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    Abstract:

    Cerebral ischemia-reperfusion injury (CIRI) refers to the recovery of blood supply after cerebral ischemia, which leads to further damage and the dysfunction of brain tissue. Modern medicine has made some progress in the prevention and treatment of CIRI, but it still faces some challenges and limitations. Therefore, it is of great clinical value to find effective interventions to prevent and treat CIRI. AMP-activated protein kinase (AMPK) and its downstream proteins are important targets for the treatment of CIRI and play key roles in the regulation of cellular energy homeostasis. Traditional Chinese medicine for CIRI has multi-target and multi-pathway activities and multiple effects. It can activate a cascade of reactions in the AMPK signaling pathway and can be used to treat CIRI by regulating autophagy, oxidative stress, inflammatory response, and apoptosis, and has achieved certain result. Therefore, this paper summarizes the structure and mechanisms of the AMPK-related signaling pathway, elaborates on its relationship with CIRI, and systematically summarizes the research status of traditional Chinese medicine’s ability to regulate the AMPK signaling pathway in the prevention and treatment of CIRI. This paper aims to provide new ideas for the prevention and treatment of CIRI using traditional Chinese medicine and the development of new drugs.

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History
  • Received:March 08,2024
  • Online: October 30,2024
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