Research progress in the application of single-cell sequencing technology in multiple sclerosis

doi:10.3969/j.issn.1671-7856.2024.10.019

Home > Archive>Volume 34, Issue 10, 2024 >161-168. DOI:10.3969/j.issn.1671-7856.2024.10.019

Research progress in the application of single-cell sequencing technology in multiple sclerosis
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                        10.3969/j.issn.1671-7856.2024.10.019
                    
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Author:
                        MA Zhihong1MA Zhihong
1. Department of Basic Medical Sciences, the 960th Hospital of PLA, Jinan 250031, China
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ZHANG Lihong1ZHANG Lihong
1. Department of Basic Medical Sciences, the 960th Hospital of PLA, Jinan 250031, China
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CAO Yuan1CAO Yuan
1. Department of Basic Medical Sciences, the 960th Hospital of PLA, Jinan 250031, China
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CHENG Ming1,2CHENG Ming
1. Department of Basic Medical Sciences, the 960th Hospital of PLA, Jinan 250031, China. 2. Department of Neurology, the 960th Hospital of PLA, Jinan 250031
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Affiliation:1. Department of Basic Medical Sciences, the 960th Hospital of PLA, Jinan 250031, China. 2. Department of Neurology, the 960th Hospital of PLA, Jinan 250031
Clc Number:R-33
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Abstract:

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by neuroinflammation and neurodegeneration. The pathogenesis of the disease is complex, and involves various central nervous system and peripheral cells. Single-cell sequencing has recently been increasingly applied in the study of neurological disorders, leading to important advances in our understanding of intercellular heterogeneity, disease development mechanisms, and treatment strategies. This review summarizes research progress in single-cell sequencing and its applications in MS.

Key words:multiple sclerosis; single-cell sequencing; central nervous system; review

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Received:April 26,2024
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Online: November 19,2024
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