Parkinson’s disease(PD) is a neurodegenerative disease that primarily affects middle-aged and older adults. Its main clinical manifestations include resting tremor, bradykinesia, myotonia, and balance disorders. Berberine is a naturally occurring isoquinoline alkaloid. Several studies over the previous decade have reported that berberine plays a crucial role in the pathophysiologic processes of a range of diseases, including playing an active role in the development of PD via different pathways. This paper systematically reviews the mechanism of action of berberine in the prevention and treatment of PD and the current status of research, to provide references for the future clinical application of berberine for the treatment of PD.