Methamphetamine(METH) is a new type of abused drug with a strong central stimulant effect. Its excitatory pathway involves a series of central higher-level functions, including drug-related rewards and motivation, learning and memory, decision-making, and execution. METH not only causes neurotoxicity, but its long-term use may also cause cognitive dysfunction, loss of personality, and may lead to serious social violence in addicts. Exosomes, as a novel cell-to-cell carrier, are involved in the occurrence and development of drug addiction, and exosome microRNAs are important biomarkers for METH addiction and are also involved in various aspects of METH-induced neurotoxicity. Eoxosmes may thus be useful therapeutic carriers providing a new approach for the diagnosis and treatment of METH abuse.