Research progress on the role and mechanisms of epigenetics in delirium diseases

doi:10.3969/j.issn.1671-7856.2025.02.012

Home > Archive>Volume , Issue 2, 2025 >116-126. DOI:10.3969/j.issn.1671-7856.2025.02.012

Research progress on the role and mechanisms of epigenetics in delirium diseases
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                        10.3969/j.issn.1671-7856.2025.02.012
                    
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Author:
                        XU XinyiXU Xinyi
1. Emergency Department, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
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MIAO ChanghongMIAO Changhong
1. Emergency Department, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
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WU FangyingWU Fangying
2. the Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310000
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XIAO LuXIAO Lu
1. Emergency Department, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
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Affiliation:1. Emergency Department, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China. 2. the Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310000
Clc Number:R-33
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Abstract:

Delirium has a high incidence and is associated with a poor patient prognosis. The pathogenesis of delirium is still unclear. Although antipsychotic drugs are the main intervention in clinical practice, there are currently no drugs that can definitively improve the long-term health-related quality of life in patients with delirium. In this study, we review research on the associations between epigenetic modifications such as non-coding RNAs, DNA methylation, and histone acetylation and the development of delirium, with the aim of providing information to support clinical decisions on the early identification and diagnosis of delirium, as well as its treatment and prognosis and the development of relevant targeted drugs.

Key words:delirium; epigenetics; non-coding RNA; DNA methylation; histone acetylation

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Received:November 07,2024
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Online: May 06,2025
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