Macrophages, as intrinsic immune cells, are an important component of the innate immune system and play an important role in immunity against Mycobacterium tuberculosis ( Mtb) infection. After infecting the organism, Mtb mainly parasitizes macrophages, where it can survive and multiply, inducing cell death via apoptosis,autophagy, pyroptosis, ferroptosis, and necroptosis. These different modes of cell death play different roles in the process of Mtb infection. This review considers the different macrophage cell-death pathways and their roles after Mtb infection, with the aim of furthering our understanding of the potential impacts on host immunity during Mtb infection,and providing references for future research into the pathogenic mechanism of Mtb and strategies of anti-tuberculosis treatment.