Application of gene-editing technique in large experimental animals
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Affiliation:

1. Laboratory Animal Center of Suzhou Medical College, Soochow University, Suzhou 215000, China.2. Heilongjiang Agricultural Products and Veterinary Feed Technology Appraisal Station, Harbin 150000

Clc Number:

R-33

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    Abstract:

    Recent rapid developments in molecular biological techniques have allowed the use of gene editing, as a means of genome modification, for the establishment of experimental animal models, with high efficiency, accuracy, and flexibility. This article mainly summarizes the construction and application of the latest gene-editing techniques in animal models, including pigs, non-human primates and dogs. It provides a theoretical reference for the application and in-depth study of gene-editing techniques in large experimental animals, which may better simulate human diseases, and for further studies of the potential pathogenesis of biomedical and human complex diseases.

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History
  • Received:June 19,2024
  • Online: May 06,2025
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