Research progress in animal models of lung “inflammation-cancer”transformation

doi:10.3969/j.issn.1671-7856.2025.03.011

Home > Archive>Volume , Issue 3, 2025 >109-136. DOI:10.3969/j.issn.1671-7856.2025.03.011

Research progress in animal models of lung “inflammation-cancer”transformation
DOI:
                        10.3969/j.issn.1671-7856.2025.03.011
                    
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                        CHEN Yajuan1,2,3CHEN Yajuan
1. Jiangxi University of Chinese Medicine, Nanchang 330004, China. 2. National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine, Nanchang 330006. 3. Jiangxi Provincial Key Laboratory of Effective Material Basis of TCM(2024SSY07102), Jiangxi University of Chinese Medicine, Nanchang 330004
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CHEN Lanying1,2,3CHEN Lanying
1. Jiangxi University of Chinese Medicine, Nanchang 330004, China. 2. National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine, Nanchang 330006. 3. Jiangxi Provincial Key Laboratory of Effective Material Basis of TCM(2024SSY07102), Jiangxi University of Chinese Medicine, Nanchang 330004
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DUAN Wenbin1,2,3DUAN Wenbin
1. Jiangxi University of Chinese Medicine, Nanchang 330004, China. 2. National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine, Nanchang 330006. 3. Jiangxi Provincial Key Laboratory of Effective Material Basis of TCM(2024SSY07102), Jiangxi University of Chinese Medicine, Nanchang 330004
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HUANG Yuqing1,2HUANG Yuqing
1. Jiangxi University of Chinese Medicine, Nanchang 330004, China. 2. National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine, Nanchang 330006
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JIN Xuhui1,2JIN Xuhui
1. Jiangxi University of Chinese Medicine, Nanchang 330004, China. 2. National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine, Nanchang 330006
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Affiliation:1. Jiangxi University of Chinese Medicine, Nanchang 330004, China. 2. National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine, Nanchang 330006. 3. Jiangxi Provincial Key Laboratory of Effective Material Basis of TCM(2024SSY07102), Jiangxi University of Chinese Medicine, Nanchang 330004
Clc Number:R-33
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Abstract:

Lung cancer is a serious pulmonary tumor, with exacerbation of chronic lung inflammation being a precursor to the development of lung cancer. Relevant animal models are widely used in experimental research, to gain a deeper understanding of the pathogenesis of lung cancer and to develop preventive treatment strategies. Induced lung cancer animal models are of particular importance for understanding the transition from chronic lung inflammation to lung cancer. Early intervention is crucial for the prevention and treatment of lung cancer. Here we review the recent literature regarding the inducing factors for lung cancer, including carcinogens ( e. g. nicotine-derived nitrosamine ketone, benzopyrene, diethylnirtosamine atmospheric fine particulate matter (PM_{2. 5} ), coal smoke, heavy metal ions,radiation, and biological infections ). We also summarize animal models of lung inflammation and cancer transformation induced by these factors, discuss the mechanisms by which relevant carcinogens induce lung cancer,analyze the advantages and limitations of the animal models, and consider future development directions. This review aims is to provide a valuable reference for the future establishment of relevant models.

Key words:“ inflammation-cancer” transformation; lung cancer; animal models; induction mechanisms; advantages; limitations

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Received:August 26,2024
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Online: May 29,2025
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