Research progress in relationship between polycystic ovary syndrome and ovarian follicle expansion and its regulatory mechanism

doi:10.3969/j.issn.1671-7856.2025.03.012

Home > Archive>Volume , Issue 3, 2025 >137-146. DOI:10.3969/j.issn.1671-7856.2025.03.012

Research progress in relationship between polycystic ovary syndrome and ovarian follicle expansion and its regulatory mechanism
DOI:
                        10.3969/j.issn.1671-7856.2025.03.012
                    
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Author:
                        ZHANG Yibo1,2ZHANG Yibo
1. Department of Physiology, Baotou Medical College, Baotou 014040, China. 2. Bayannur Clinical Medical College,Baotou Medical College, Baotou 014040
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YANG Li1,3YANG Li
1. Department of Physiology, Baotou Medical College, Baotou 014040, China. 3. School of Medical Technology and Anesthesiology, Baotou Medical College, Baotou 014040
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FENG Shiguang1,3FENG Shiguang
1. Department of Physiology, Baotou Medical College, Baotou 014040, China. 3. School of Medical Technology and Anesthesiology, Baotou Medical College, Baotou 014040
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SUN Jie4SUN Jie
4. Department of Pathophysiology, Baotou Medical College, Baotou 014040
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HAO Xiaoqiong1HAO Xiaoqiong
1. Department of Physiology, Baotou Medical College, Baotou 014040, China
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Affiliation:1. Department of Physiology, Baotou Medical College, Baotou 014040, China. 2. Bayannur Clinical Medical College,Baotou Medical College, Baotou 014040. 3. School of Medical Technology and Anesthesiology, Baotou Medical College, Baotou 014040. 4. Department of Pathophysiology, Baotou Medical College, Baotou 014040
Clc Number:R-33
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Abstract:

Ovarian follicle expansion is an important part of their growth and development into dominant follicles, and is regulated by a variety of molecules and signals, including follicular cavity formation, follicular fluid accumulation, and granulosa cell proliferation. Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disease in women, and patients mainly present with increased preantral follicles and polycystic ovarian lesions caused by inadequate ovarian follicle expansion. This review summarizes recent research developments concerning the physiological process of ovarian follicle expansion and the related regulatory factors and mechanisms.We also consider the possible factors restricting ovarian follicle expansion in patients with PCOS, to provide a theoretical basis for follicular dysplasia, ovulation disorders and other diseases caused by abnormal ovarian follicle expansion.

Key words:ovarian follicle expansion; follicular cavity formation; follicular fluid accumulation; granulosa cell proliferation; polycystic ovary syndrome

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Received:October 15,2024
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Online: May 29,2025
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