Research progress in animal models and related evaluation indexes of laryngopharyngeal reflux disease
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1. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China. 2. Peking University First Hospital, Beijing 100034. 3. Beijing Changgeng Hospital Affiliated to Tsinghua University, Beijing 102218. 4. School of Basic Medicine, Shanxi University of Traditional Chinese Medicine, Taiyuan 030619

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R-33

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    Abstract:

    Laryngopharyngeal reflux disease (LPRD) occurs in the upper respiratory tract and the upper digestive tract. Its pathogenesis is complex and there a lack of effective treatments. Suitable animal models and standard evaluation method are needed to explore the pathogenesis of this disease and to develop new therapeutic drugs. New Zealand rabbits are commonly used to model LPRD, via balloon dilatation. The standard evaluation method for LPRD include symptom observation and evaluation, imaging evaluation, and pH monitoring. This review considers the animal models and evaluation indexes currently used for pharyngeal reflux with reference to the global literature, to provide a reference for future research.

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History
  • Received:August 21,2024
  • Revised:
  • Adopted:
  • Online: July 04,2025
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