Methamphetamine use disorder (MUD) is a refractory disorder with limited treatment options.There are evidences that neuropeptides might be a new target for the treatment of MUD. Studying the regulatory mechanism of neuropeptides in MUD may provide new options for treatment. However, there are many kinds of neuropeptides, the mechanism of action is complex, and clinical drug references are limited. This review focuses on orexin (OX), oxytocin (OT), vasopressin (VP), neurotensin (NT), neuropeptide S (NPS), neuropeptide Y (NPY), somatostatin (SST), pituitary adenylate cyclase-activating peptide (PACAP), vasoactive intestinal peptide (VIP), glucagon-like peptide-1 (GLP-1), and other neuropeptides as well. The regulatory role and mechanism of peptides in MUD are summarized, providing new directions for research and supporting the application of neuropeptides in the treatment of MUD.