Most laboratory animal centers in colleges and universities have adopted or developed management systems for laboratory animals; however, these systems vary significantly in terms of functional modules, management refinement level, and operational efficiency. Based on an analysis of the current status of laboratory animal management systems in colleges and universities, combined with the practice experience of our institution, this study develops a refined, full-process information management system centered on cage, which significantly improves the efficiency and transparency of laboratory animal management, enhances the level of refined management and quality control, and promotes resource integration and open sharing. This system provides a new approach for the refined management of laboratory animals in colleges and universities.