【Abstract】 Objective: To establish the experimental ischemic vertigo rat model for the research of the anti-vertigo drugs. Methods: The rat model of ischemic vertigo was induced by the right common carotid artery (CCA) and subclavian artery (SCA) ligation. The escaped latency from electricity of rats was recorded to measure the degree of vertigo, and the blood flow of right vestibular nucleus was determined for 5 min before modeling and 30 min after modeling. The rate change of blood flow was calculated to evaluate the ischemic level. Results: 1.The latency of the model rats significantly prolonged when compared with the sham rats (P<0.01), which indicated that the experimental ischemic vertigo rat model was established. In addition, the latency of rats was remarkably decreased after treated with difenidol hydrochloride tablets and tianbaoning tablets, when compared with the model rats (61.9% and 52.0%, respectively, P<0.01). 2. The blood flow volume of right vestibular nucleus of the model rats reduced obviously after ligating the right CCA and SCA when compared with the sham rats ( P<0.01), which demonstrated the success of the model. The blood flow volume of right vestibular nucleus was significantly improved by treating with tianbaoning tablets after ligation, and the blood flow increased 92.8% at 5min, 83.8% at 10min, 77.3% at 15 min,77.9% at 20 min,65.7% at 25 min,55.8% at 30 min after ligation, when compared with the model group (P<0.01). Conclusion: The experimental ischemic vertigo rat model could be induced by the right common carotid artery and subclavian artery ligation, which can be used for the research on the mechanism of anti-vertigo drugs.