Objective： To explore the relevance of Wagner electrocardiogram QRS score to myocardial infarction area in diabetes mini-pigs. Methods： 12 Obama mini-pigs were randomly divided into diabetic group (n=6) and normal control group (n=6). The diabetes models were established by administering STZ of 150 mg/kg once intravenous. Fasting blood glucose were measured before and 1 day, 3 days and 7 days after drug administration. When fasting blood glucose consistently elevated (≥7.0 mmol/L), the model pigs were determined to be with diabetes. Second, selectively ligating the left anterior descending artery between diagonal branch 1 and 2 in diabetes and normal control mini-pigs, and perform QRS scoring at 10 min, 30 min, 1 h, 48 h after ligation; At the end point, the myocardial infarction size were measured by Evan 's blue and TTC staining; and the correlation of QRS score and myocardial infarction size were analyzed. Results: All animals happened typical pathological changes of myocardial ischemia; pathological Q wave formed, QRS scores in diabetes group was obviously higher than that in control group (6.9?.4 vs. 4.1?.8, P<0.05); Pathological staining results also showed that the infarction area was significantly larger than that in control group (29.2?.1% vs.15.3?.4%, P<0.05); the correlation coefficient was 0.92. Conclusion: Acute myocardial ischemia in diabetic mini-pigs were more likely to result in myocardial tissue necrosis, infarction area was larger; The myocardial infarction area judged by electrocardiogram QRS scoring had good correlation with pathological situations.