Objective Using Morris water maze to evaluate the effect of curcumin on cognitive function of APPswe/PS1dE9 double transgenic mice. Methods 3-month old APPswe/PS1dE9 dtg mice were randomly divided into model group, Rosiglitazone group and curcumin large, medium and small dose group( n=6), with age-matched C57BL/6J mice of the same genetic background as normal control group. Medication was given once a day by intragastric administration for 6 months. Application of Morris water maze to test APPswe/PS1dE9 double transgenic mice spatial learning and memory ability. Results Curcumin to APPswe/PS1dE9 double transgenic mice spatial learning and memory disabilities have improvement effect, especially in curcumin-M dose group in the more obvious effects. Conclusion Curcumin can improve learning and memory ability of APPswe/PS1dE9 double transgenic mice.