Objective To Comparative study of three anesthetic methods in hemorrhagic shock experiments of Bama Minipigs. Methods Bama Minipigs 24, the average into three groups are Intramuscular ketamine group (A group), intravenous propofol group (B group), propofol intravenous anesthesia with sevoflurane group (C group). Respectively, before anesthesia (T0), after induction (T1), after catheter (T2), HS instantly (T3), HS after 30min (T4), recovery (T5), resuscitation after 30min (T6) and pull the end of the experiment tube after 10 min (T7), pigs in each group were observed and recorded heart rate (HR), mean arterial pressure (MPAP), nasal temperature (NT), pH value and oxygen saturation (SPO2) and other indicators, while recording the induction of anesthesia time, restoration of spontaneous breathing time, intraoperative anesthetic additional number of cases, number of cases of postoperative adverse reactions. Results Three groups of Bama pig experiments predecessor length, weight, volume and put the blood hemoglobin general condition showed no significant difference (P> 0.05); A group of anesthesia to be ineffective, surgery and have to be repeated dosing restless phenomenon surgery after vomiting and other adverse reactions; B group anesthesia is relatively stable, but still restless phenomenon during surgery and need additional anesthetic; C group anesthesia best short induction period, intraoperative safety, restoration of spontaneous breathing short time, intraoperative no adverse effects. Conclusion Propofol intravenous anesthesia combined with sevoflurane anesthesia induction time is short, the anesthetic effect is good, smooth and safe surgery, postoperative recovery fast, suitable for large animal anesthesia.