Chronic lung diseases (CLD) include chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, etc. Studies have shown that CLD is closely related to the disorder of lipid metabolism. Therefore, lipids, as biomarkers of CLD, may be of great value in the diagnosis, prevention and monitoring of disease treatment.This review mainly discusses four aspects of lipidomics, selection of clinical samples for lipidomics, discovery of biomarkers for CLD, and differentiation of TCM syndromes for CLD.