Progress of mitochondrial mass control system in the pathogenesis of septic cardiomyopathy
Author:
Affiliation:

1. The First Clinical Medical School Gansu University of Chinese Medicine 2.The 940 Hospital of Joint Service Support Forces of the Chinese People Liberation Army;2.Kunming Children&3.#39;4.s Hospital;5.South Yunnan Central Hospital of Yunnan Province;6.中国人民解放军联勤保障部队第九四〇医院

Fund Project:

Molecular mechanism of exacerbation of sepsis caused by B cell dysfunction in children

  • Article
  • | |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • | |
  • Comments
    Abstract:

    Septic cardiomyopathy (SIC) is a frequently observed organ dysfunction in sepsis, characterized by high mortality and poor prognosis. Understanding the complex pathogenesis of SIC and developing effective therapeutic tools are critical issues that require attention. Previous studies have demonstrated the significant role of mitochondrial dysfunction in the development of SIC. In the presence of SIC and resulting mitochondrial dysfunction, aberrant regulation of the mitochondrial quality control system (MQC) can exacerbate cardiomyocyte injury. Recent studies have demonstrated that the mitochondrial quality control system (MQC) maintains mitochondrial dynamic homeostasis through its regulation of mitochondrial biogenesis, fusion/fission, and autophagy. Consequently, this article provides an overview of the role of MQC in SIC pathogenesis, reviews the latest studies, and analyzes its potential as a therapeutic target.

    Reference
    Related
    Cited by
Get Citation
Related Videos

Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:July 15,2023
  • Revised:October 11,2023
  • Adopted:June 17,2024
Article QR Code