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Research progress on the involvement of macrophages in myocardial ischemia reperfusion injury mediated by NF-κB signaling pathway
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The First Affiliated Hospital of Henan University of CM, Heart Center/National Regional（Traditional Chinese Medicine）Cardiovascular Diagnosis and Treatment Center

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)(82274316) ；Henan Province Chinese medicine scientific research special topic(2019JDZX2071，2022JDZX037)

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    Abstract:

    Myocardial ischemia reperfusion injury（MIRI）has become one of the most serious complications affecting the clinical outcome of patients with cardiovascular diseases. The immune inflammatory response of macrophages is closely related to the occurrence and development of MIRI.Many studies have shown that the NF-κB signaling pathway can participate in MIRI regulation by influencing the polarization and inflammatory state of macrophages, pyrodeath, infiltration and other functions, and is a potential target for MIRI therapy.Therefore, this article will review the research progress of NF-κB signaling pathway between macrophage function and MIRI regulation.

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History
  • Received:October 24,2023
  • Revised:February 28,2024
  • Adopted:May 16,2024
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