Volume adjusting anion channel (VRAC) in vertebrate cells and each type of general expression in tumor cells. Leucine-rich repeat containing 8A(LRRC8A) and its four homologous family members (LRRC8B-E), of which LRRC8A is an essential subunit. It has been confirmed that LRRC8A/VRAC is involved in the proliferation, migration, invasion and multi-drug resistance of tumor cells through various signaling pathways. This ion transporter has shown good potential in killing tumor cells and preventing the development of tumor, and can be used as a new target for tumor therapy. Therefore, this paper reviews the latest research on the involvement of LRRC8A/VRAC in tumorigenesis and development, including the molecular structure, function and regulation of LRRC8A/VRAC in tumor and immune cells, with emphasis on the application of LRRC8A/VRAC in tumor diagnosis and immunotherapy, in order to provide reference for exploring LRRC8A/VRAC as a new target of tumor therapy.