Research progress on anti-tumor effects of LRRC8A/VRAC ion channels

Research progress on anti-tumor effects of LRRC8A/VRAC ion channels
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                        yangrunze1yangrunze
Basic Medical College of Gansu University of Chinese Medicine
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huyaohua2,3,4huyaohua
Yan''an University School of Medicine
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qinjing5qinjing
Laboratory Animal Center of Air Force Military Medical University
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wangyongfeng6wangyongfeng
Basic Medical College of Gansu University of Chinese MedicineBasic Medical College of Gansu University of Chinese Medicine
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shichanghong7shichanghong
Laboratory Animal Center of Air Force Military Medical UniversitLaboratory Animal Center of Air Force Military Medical University
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Affiliation:1.Basic Medical College of Gansu University of Chinese Medicine;2.Yan'3.'4.an University School of Medicine;5.Laboratory Animal Center of Air Force Military Medical University;6.Basic Medical College of Gansu University of Chinese MedicineBasic Medical College of Gansu University of Chinese Medicine;7.Laboratory Animal Center of Air Force Military Medical UniversitLaboratory Animal Center of Air Force Military Medical University
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Fund Project:(GZKZ-2021-10)Funded by National Natural Science Foundation of China (NO. 82160871); Supported by Natural Science Foundation of Gansu Province (NO. 22JR5RA591); Project of Gansu Provincial Administration of Traditional Chinese Medicine (NO. GZKZ-2021-10)

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Abstract:

Volume adjusting anion channel (VRAC) in vertebrate cells and each type of general expression in tumor cells. Leucine-rich repeat containing 8A(LRRC8A) and its four homologous family members (LRRC8B-E), of which LRRC8A is an essential subunit. It has been confirmed that LRRC8A/VRAC is involved in the proliferation, migration, invasion and multi-drug resistance of tumor cells through various signaling pathways. This ion transporter has shown good potential in killing tumor cells and preventing the development of tumor, and can be used as a new target for tumor therapy. Therefore, this paper reviews the latest research on the involvement of LRRC8A/VRAC in tumorigenesis and development, including the molecular structure, function and regulation of LRRC8A/VRAC in tumor and immune cells, with emphasis on the application of LRRC8A/VRAC in tumor diagnosis and immunotherapy, in order to provide reference for exploring LRRC8A/VRAC as a new target of tumor therapy.

Key words:volume regulated anion channel (VRAC); leucine-rich repeat containing 8A (LRRC8A); tumor; proliferation; invasion; multidrug resistance; immunity;

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Received:February 01,2024
Revised:May 31,2024
Adopted:October 30,2024
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