Research progress on the mechanism of D-galactose-induced brain aging model: A review

Research progress on the mechanism of D-galactose-induced brain aging model: A review
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                        ZHU Ziyue1ZHU Ziyue
College of Basical Medical Science,Heilongjiang University of Chinese Medicine
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JIN Meiling1JIN Meiling
College of Basical Medical Science,Heilongjiang University of Chinese Medicine
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XU Xiangyue2XU Xiangyue
Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine
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LIU Qing2LIU Qing
Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine
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ZHU Jiaxue1ZHU Jiaxue
College of Basical Medical Science,Heilongjiang University of Chinese Medicine
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FU Mingjun1FU Mingjun
College of Basical Medical Science,Heilongjiang University of Chinese Medicine
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LEI Xia2LEI Xia
Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine
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ZHANG Ning3ZHANG Ning
Heilongjiang University of Chinese Medicine
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Affiliation:1.College of Basical Medical Science,Heilongjiang University of Chinese Medicine;2.Wuxi Affiliated Hospital of Nanjing University of Traditional Chinese Medicine;3.Heilongjiang University of Chinese Medicine
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Fund Project:The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)；Wuxi Municipal Health Commission Young and Middle-aged Top Talents Funding Program；Research project of Wuxi Municipal Health Commission

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Abstract:

As a normal physiological substance, D-galactose (D-gal) can induce a process similar to natural brain aging in vivo and in vitro under excessive intake, so it is widely used to induce brain aging model in China. The model of brain failure induced by D-galactose has the advantages of short time, low cost and significant effect, but its inducting mechanism is complex and diverse, and the relationships between the mechanisms are not clear, which leads to the limitation of the practical application of the model. This article reviews the in vivo metabolism of D-galactose and the various mechanisms of inducting brain aging, as well as the links between the mechanisms, in order to provide reference for the application and development of this model and the in-depth study of brain aging.

Key words:brain aging; D-galactose; model mechanism

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Received:March 05,2024
Revised:May 14,2024
Adopted:August 26,2024
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