Depression is a psychosomatic disorder. In recent years, the rising incidence of depression around the world, bringing a heavy economic burden on society. The active substances extracted from the Chinese herb Morinda officinalis can soothe depression and calm the mind, tonify the kidney and benefit the intellect, and can also regulate monoamine neurotransmitter levels, enhance neuroplasticity, regulate the HPA axis, and regulate cytokine levels in antidepressant, as well as improve cognitive disorders in patients to a certain extent. Based on the hypothesis of the pathogenesis of depression, this paper summarises the role of Morinda officinalis oligosaccharides in antidepressant, and provides theoretical basis for the research and development of Morinda officinalis oligosaccharides antidepressant drugs.