Alzheimer"s Disease (AD) is a degenerative neurological disorder that can lead to cognitive decline, mental behavior abnormalities, and reduced ability to daily lives. Tryptophan is an essential amino acid for the human body and is produced by three main metabolic pathways, namely kynuridine, 5-hydroxytryptamine (5-HT) and indole derivatives. Influencing the metabolites of tryptophan can lead to ameliorated neuroinflammation in the brain and significantly improvdcognitive ability, while the occurrence and development of AD.is affected and intervened. In this paper, we reviewed the research literature on tryptophan metabolism intervention in AD in recent 3 years from CNKI, PubMed and other databases.