Vascular smooth muscle cell phenotype switch and Cell pyroptosis in the role and research progress of Abdominal aortic aneurysm
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1.Graduate School of Hebei Medical University;2.Graduate School of Hebei North University;3.Graduate School, North China University of Science and Technology;4.Department of Biochemistry, School of Basic Medicine, Hebei Medical University;5.Clinical Medicine Research Cener, Hebei General Hospital

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    Abstract:

    Abdominal aortic aneurysm (AAA) is a hidden and fatal disease, but its underlying developmental mechanism remains unclear. It has been found that phenotypic switching of vascular smooth muscle cells and pyroptosis are two biological processes closely related to the appearance and progress of AAA, which may become an important theory to reveal the mechanism of AAA and provide a new direction for the diagnosis and treatment of AAA. In this review, we will discuss the phenotypic switch of VSMCs and the regulatory relationship between cell pyroptosis and AAA.

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History
  • Received:May 07,2024
  • Revised:October 01,2024
  • Adopted:October 25,2024
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