PD is a highly complex neurodegenerative disease, and its pathogenesis is influenced by DNA methylation, histone modification, and non-coding RNA. In research on Parkinson"s brain tissue and blood, it has been shown that changes in DNA methylation/histone modification levels, variations in ncRNA and its target genes may trigger or exacerbate the pathogenesis of neurodegeneration, and serve as potential non-invasive biomarkers for Parkinson"s disease. Exercise can improve neurodegenerative diseases caused by aging and PD by reversing epigenetics. This article reviews the pathogenesis of epigenetics in Parkinson"s disease, explores the role of exercise in it, and provides theoretical reference for improving Parkinson"s disease by regulating epigenetics through exercise.