Research progress of epigenetic modification in renal damage caused by hyperhomocysteinemia
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Affiliation:

1.Hainan Medical College;2.National Health Commission Key Laboratory of Metabolic Cardiovascular Disease Research;3.General Hospital of Ningxia Medical University

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    Abstract:

    【】Chronic kidney disease (CKD) is a group of clinical syndromes of chronic kidney structure and dysfunction caused by various causes, with high treatment costs and poor prognosis. As an important regulator of gene expression, studies have shown that the effect of epigenetic modification on gene expression and cell function plays a key regulatory role in the occurrence and development of CKD. Homocysteine (Hcy) is a common amino acid-containing thiol group in the body. As an independent predictor of end-stage renal disease morbidity and mortality, HHcy involves many organs and is highly harmful. This article introduces the relationship between HHcy and chronic renal injury, and further reviews the research progress of epigenetic modification in the mechanism of homocysteine-mediated chronic renal injury, aiming to gain a deeper understanding of the occurrence and development of chronic renal disease The process and its mechanism provide some new ideas and theoretical basis for the research of chronic kidney disease.

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History
  • Received:May 14,2024
  • Revised:December 04,2024
  • Adopted:May 06,2025
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