【】Chronic kidney disease (CKD) is a group of clinical syndromes of chronic kidney structure and dysfunction caused by various causes, with high treatment costs and poor prognosis. As an important regulator of gene expression, studies have shown that the effect of epigenetic modification on gene expression and cell function plays a key regulatory role in the occurrence and development of CKD. Homocysteine (Hcy) is a common amino acid-containing thiol group in the body. As an independent predictor of end-stage renal disease morbidity and mortality, HHcy involves many organs and is highly harmful. This article introduces the relationship between HHcy and chronic renal injury, and further reviews the research progress of epigenetic modification in the mechanism of homocysteine-mediated chronic renal injury, aiming to gain a deeper understanding of the occurrence and development of chronic renal disease The process and its mechanism provide some new ideas and theoretical basis for the research of chronic kidney disease.