Effects of hypoxic preconditioning on NR2B in mouse hippocampal cell and HT22 cell
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1.Department of ICU, The Third People'2.'3.s Hospital of Longgang District;4.Department of Public Health, Krirk University, Bangkok;5.Key Laboratory of Hypoxic Translational Medicine of Inner Mongolia,;6.Translational Medicine Center, The Third People'

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    Abstract:

    objective: N-methyl-D-aspartate (NMDA) receptor subunit 2B (NR2B) and its phosphorylation are involved in cerebral ischemia/hypoxic neural injury. Hypoxic preconditioning (HPC) serves as an endogenous protective intervention to protect the brain from ischemic/hypoxic injury. This study intends to explore the effect of HPC on NR2B and its two tyrosine sites phosphorylation (1252 and 1336) in hippocampal cells through in vivo and in vitro experiments, and explore its role in HPC neuroprotection.

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History
  • Received:May 15,2024
  • Revised:June 17,2024
  • Adopted:August 02,2024
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