Cerebral ischemia/reperfusion injury (CIRI) is a significant pathophysiological process affecting the prognosis of patients with ischemic stroke. Its mechanism is complicated and has not been completely clarified. Long non-coding RNA (LncRNA) is a class of non-coding RNA (ncRNA). Early studies focused on its relationship with tumor-related diseases. Recent studies have found that, It is also closely related to the pathological process of ischemia/reperfusion injury. Therefore, in this paper, the relevant mechanisms of LncRNA in cerebral ischemia-reperfusion injury were reviewed.