ZHANG Xinyi
the First Clinical Medical College of Zhejiang Chinese Medicinal UniversityCAI Hongwen
Department of Cardiology,Zhejiang Provincial Hospital of Traditional Chinese Medicine1.the First Clinical Medical College of Zhejiang Chinese Medicinal University;2.Department of Cardiology,Zhejiang Provincial Hospital of Traditional Chinese Medicine
The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)
Atherosclerosis(AS), the primary pathological basis of coronary heart disease, is of significant importance in the prevention and treatment of coronary heart disease. Neuropilin-1 (NRP1), a member of the neuropilin receptor family, is closely associated with various growth factors, including vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β). NRP1 influences the progression of atherosclerosis through its crucial roles in angiogenesis, inflammatory responses, and the sensing of shear stress on the vascular endothelium. Therefore, a thorough exploration of the mechanisms underlying NRP1's role in atherosclerosis and the development of NRP1-targeted therapeutic strategies will provide new insights into the diagnosis and treatment of atherosclerosis.