【】Colorectal cancer (CRC), as one of the most common malignant tumors that threaten human life, seriously affects the quality of life of patients. In recent years, SHP2 has become a hot topic in the field of cancer and has been proven to have a close relationship with colorectal cancer. SHP2, Encoded by the PTPN11 gene, it is a non receptor tyrosine kinase commonly present in various tissues and cells of the human body. Existing research shows that, SHP2 plays a crucial role in regulating CRC and colitis associated colon cancer (CAC). And with the emergence of SHP2 allosteric inhibitors, SHP2 has become a new potential therapeutic target for CRC patients. This article mainly reviews the structure of SHP2 and its impact in CRC and CAC.