Micro-ribonucleic acid (miRNA) is a class of endogenous RNA molecules with a length typically ranging from 19 to 25 nucleotides.They regulate gene expression levels by identifying homologous sequences and intervening in transcription, translation,or epigenetic processes.miRNAs exhibit potential application value in the pathogenesis, progression,and treatment of deep vein thrombosis (DVT).DVT refers to the abnormal coagulation of blood within the lumen of the deep veins,blocking the venous lumen and leading to venous return obstruction, which is more common in the lower limbs.The detachment of thrombus into the lungs can lead to death.This article comprehensively reviews the diverse mechanisms of action of miRNAs in DVT in recent years.Given that the regulation of miRNA expression through targeted therapeutic approaches may promote the recovery of DVT,this article also discusses in detail the potential applications of miRNAs in the clinical diagnosis and treatment of DVT.This article aims to provide valuable references and insights for clinical and basic research in the field of DVT.