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Research progress of exosomal miRNAs in methamphetamine-induced neurotoxicity and drug development
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1.School of Forensic Medicine,NHC Key Laboratory of Drug Addiction Medicine,Kunming Medical University,Kunming,Yunnan,China;2.Department of Human Anatomy and Embryology,School of Basic Medical Sciences,Kunming Medical University,Kunming,Yunnan,China

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    Abstract:

    As a new type of abused drug, methamphetamine (METH) has a strong central stimulant effect, and the excitatory pathway involved a series of central higher-level functions, including drug-related rewards and motivation, learning and memory, decision-making and execution, etc. Methamphetamine not only causes neurotoxicity in the body, but long-term use could cause cognitive dysfunction, loss of personality, and serious social violence in addictions. Exosomes, as a new carrier of cell-to-cell communication, were involved in the occurrence and development of drug addiction, and exosome miRNAs were not only important biomarkers for methamphetamine addiction, but also involved in various aspects of methamphetamine induced neurotoxicity, which could be used as a therapeutic carrier to provide new ideas for the diagnosis and treatment of methamphetamine abuse.

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History
  • Received:June 27,2024
  • Revised:September 09,2024
  • Adopted:December 26,2024
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