Recent progress of research into the role of lncRNA in the molecular mechanism of pulmonary hypertension

Recent progress of research into the role of lncRNA in the molecular mechanism of pulmonary hypertension
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                        WU Daoxiong1WU Daoxiong
Department of Clinical Laboratory, the Second Affiliated Hospital of Kunming Medical University
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LI Yanjin2LI Yanjin
Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Kunming Medical University
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HU Ying1HU Ying
Department of Clinical Laboratory, the Second Affiliated Hospital of Kunming Medical University
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WANG Yuming3WANG Yuming
Department of Clinical Laboratory,the Second Affiliated Hospital of Kunming Medical University
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HU Wei4HU Wei
Department of Cardiovascular Medicine,the First Affiliated Hospital of Kunming Medical University
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MA Run3MA Run
Department of Clinical Laboratory,the Second Affiliated Hospital of Kunming Medical University
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Affiliation:1.Department of Clinical Laboratory, the Second Affiliated Hospital of Kunming Medical University;2.Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Kunming Medical University;3.Department of Clinical Laboratory,the Second Affiliated Hospital of Kunming Medical University;4.Department of Cardiovascular Medicine,the First Affiliated Hospital of Kunming Medical University
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Fund Project:Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Special Fund for Applied Basic Research at the top level(202101AY070001-130)；Sub-topic project of Yunnan Provincial Cardiovascular and Cerebrovascular Clinical Medical Research Center (ZX2019-03-01);Graduate Student Innovation Fund of Kunming Medical University (2024S311);Graduate Student Innovation Fund of Kunming Medical University (2024S287)

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Abstract:

Pulmonary hypertension (PH) is a fatal disease characterized by pulmonary vascular remodeling that ultimately leads to right heart failure and death. Current PH treatment is suboptimal, with no substantial improvement in the overall survival of patients with advanced PH. Despite the current partial progress has been made in the pathogenesis of PH, more exploration at the molecular level is needed to develop more effective treatments for PH. Recent researches have shown that long non-coding RNA (lncRNA) plays an important regulatory function in the pathophysiological process of PH, and has become a potential disease biomarker and therapeutic target. In this paper, we review the molecular mechanisms of lncRNA in PH in recent years.

Key words:lncRNA;pulmonary hypertension;molecular mechanism

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Received:July 02,2024
Revised:September 26,2024
Adopted:October 22,2024
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