Analysis of Vascular Restenosis Animal Model Based on Data Mining
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Affiliation:

1.Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine;2.Beijing University of Chinese Medicine

Fund Project:

Science and Technology Innovation Project of Chinese Academy of Traditional Chinese Medicine (CI2021A00910); National Natural Science Foundation of China (81973674)

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    Abstract:

    Objective: To analyze the modeling methods and evaluation methods of vascular restenosis animal model in recent 10 years, and provide reference for improving vascular restenosis animal model. Methods: Literature related to vascular restenosis was retrieved from Chinese and English mainstream databases from 2013 to 2023. Data of experimental animal strain, modeling method, modeling cycle and detection method were extracted from the included literature, and a database was established by Excel for summary analysis. Results: Among the 122 articles, the experimental animal strains were mainly rats, rabbits and pigs, and the sex was mainly male. The most commonly used modeling method was balloon injury, and the modeling cycle was mainly within 4W-8W. The detection indexes were mainly histopathology, accounting for 37.18%, including routine hematoxylin-eosin staining, Masson staining and EVG staining. Conclusion: At present, the translatability of porcine vascular restenosis model is more in line with expectations, but the cost is high and it is difficult to popularize. Rats and rabbits are still the mainstream. Balloon injury is the main mode of modeling. Different vascular restenosis animal models and modeling methods have advantages and disadvantages, and should be selected according to the experimental purpose.Animal models of vascular restenosis still have some limitations, and it is inevitable to seek more ideal animal models in the future.

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History
  • Received:August 26,2024
  • Revised:November 19,2024
  • Adopted:February 18,2025
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