Ferroptosis is mainly related to iron, lipid and amino acid metabolic pathways, which contribute to the production of reactive oxygen species, mitochondrial damage and finally cell death. Ferroptosis primarily involves iron, lipid, and amino acid-related metabolic pathways that contribute to the production of lipid reactive oxygen species. In recent years, ferroptosis has been recognized as a key regulatory mechanism during tumor development, and it is no exception in acute leukemia. The purpose of this article is to review ferroptosis and its mechanism in the development of acute leukemia, and to explore how ferroptosis affects acute leukemia,which provides new ideas for future research and treatment of leukemia.