Progress in the animal model of pollen-induced allergic rhinitis
Affiliation:

1.Tianjin University of Traditional Chinese Medicine;2.Inner Mongolia Medical University

Fund Project:

National Natural Science Foundation of China (82105045)

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    Abstract:

    【Abstract】Pollen allergen-induced allergic rhinitis (AR), also known as seasonal allergic rhinitis (SAR), typically manifests during the pollen dissemination period of anemophilous plants. Over the past three decades, the prevalence of SAR has more than doubled. The etiology of SAR is multifaceted, encompassing various elements such as pollen allergens, environmental and climatic conditions, genetic predispositions, and the immunological status of individuals.Animal models serve as a critical tool in elucidating the mechanisms underlying AR and in advancing the development of efficacious preventive and therapeutic strategies. This review synthesizes the pertinent literature on pollen-sensitized AR animal experiments conducted both domestically and internationally over recent years. It systematically delineates the factors influencing the efficacy of these models, including the selection of animal strains, the production and associated challenges of sensitizing agents, specifically pollen antigens, the utilization and limitations of adjuvants, the procedural steps involved in model creation, and the methodologies for evaluating model effectiveness.The insights provided herein are intended to offer guidance and support for the development of appropriate animal models of pollen-induced AR, thereby facilitating both fundamental and applied research in this area.

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History
  • Received:September 02,2024
  • Revised:September 19,2024
  • Adopted:December 27,2024
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