The rRole of nitric oxide synthase in the pathogenesis of Alzheimer"s disease
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1.Department of Physiology,Fuzhou Medical College of Nanchang University,Jiangxi,Fuzhou;2.Key Research Laboratory of Chronic Disease, Fuzhou Medical University, Jiangxi, Fuzhou;3.Technology Innovation Center of Chronic Disease Research in Fuzhou City, Fuzhou Science and Technology Bureau, Fuzhou;4.Department of Physiology, Fuzhou Medical College of Nanchang University;5.Key Research Laboratory of Chronic Disease, Fuzhou Medical University;6.Technology Innovation Center of Chronic Disease Research in Fuzhou City, Fuzhou Science and Technology Bureau;7.Experimental Center of Pathogen Biology, Basic College of Medicine

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    Abstract:

    Nitric oxide synthase (NOS) and its produced nitric oxide (NO) involve in learning and memory functions. There is increasing evidence that NOS plays an important role in the pathogenesis of Alzheimer's disease (AD) by influencing β-amyloid protein (Aβ) deposition, neuroinflammation, oxidative stress, abnormal microglia activation , damaged synapse , autophagy, abnormal mitochondrial function of nerve cells, and cerebral hypoperfusion or vascular endothelial cell injury. This article summarizes the role of NOS in the pathogenesis of AD in recent years, which will provide new feasible targets for the prevention and treatment of AD.

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History
  • Received:December 21,2024
  • Revised:March 20,2025
  • Adopted:June 23,2025
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