Objective? To observe the effects of four different modeling methods on the hypothalamus ?pituitary ?adrenal (HPA) axis, blood rheology, platelet aggregation rate and myocardial ischemia in rats, and to provide new ideas for the establishment of a rat model of “double heart” disease that is more in line with clinical diagnosis and treatment characteristics. Methods ?Sixty-nine male SD rats were randomly divided into the normal group, the chronic unpredictable mild stimulation (CUMS) group, the isoproterenol (ISO) group, the high-fat diet(HF