Abstract:In trauterine surgery were performed at 116-125 gestational days in 16 ewes for the insertion of vesicular catheters at fetal abdominal aorta from femoral artery or shin artery,to build an animal model of fetal distress induced by injected microsphere 0.5ml into the vesicular catheter of fetal abdominal aorta once per 15 minutes.The results indicated that many microspheres appeared in small artery of placenta,two placental tissues around vesicular which was blocked with microsphere was showed degeneration and necrosis.Brain tissue in test group showed acute pathologic changes of degeneration and necrosis.It was suggested that injection of microsphere from fetal abdominal aorta can model the process of fetal distress,and companying neural damaged.

Abstract:本文观察了一次性经腹腔注射氯乙醇（３０ｍｇ／ｋｇＢ．Ｗ．）的急性染毒大鼠３，６，１２，２４ｈ等四个不同时点肝脏的超氧化物歧化酶、谷胱甘肽过氧化物酶等抗氧化酶活力及脂质过氧化物—丙二醛含量的变化关系，结果发现氯乙醇急性染毒组肝脏中上述的抗氧化酶活性于所设四个时点中均比对照组低（Ｐ＜０．０１及０．０５），而同时丙二醛含量高于对照组（Ｐ＜０．０１及０．０５），提示氯乙醇急性染毒大鼠中肝脏抗氧化酶活性受氯乙醇毒性所抑制，出现肝脏脂质过氧化并造成肝损害。同时，本文也发现氯乙醇急性染毒大鼠血清中丙二醛含量与肝脏丙二醛含量存在着高度密切的正相关关系（Ｐ＜０．０１），且血清中丙二醛含量比谷丙转氨酶活性早升高，提示血清丙二醛可能可以作为检测氯乙醇急性肝损害较为敏感的指标

Abstract:Obese mouse was induced in mouse by feeding with high dose lipids and protein containg food.The coposed dieting agent for childeren (CDAC) was given to the animals in two different doses.It was found that feeding the obese mouse with CDAC can reduce the body weight and serum lipid level of the animals,but the high dose group showed greater effect than the low dose group.It is suggested that the CDAC can be of help in the treatment of simple obese with or without hyperlipidemia but the dose may be greater in the former.

Abstract:The study was carried out to assess the effects of Paolifen on the activities of Super oxide Dismutase (SOD) and the contents of Lipid Peroxidize (LPO) of rat,The activities of SOD was determined with fast method.And malondialdehyde (MDA) was determined by TBA fluorescence,The SOD activities of rat liver and serum was a significant increase in the experimental groups of Paolifen (P<0.05).The contents of LPO in three groups taking Paolifen were much lower than that of the control group.It is suggested that Paolifen have an action of anti oxidate,scavenging the free radicals.

Abstract:It is reported that an rate infection with Pasteurella Pneumotropica in clean KM mice.The study included clinic and pathologic observation,pathogenic diagnosis and prevalence survey.It was observed that morbidity was 3.8% in the infected mice.The sick mice with the age about 3 weeks showed the normal general condition,but conjunction,little pus swelling in eye rim when autopsy was observed.Pasteurella pneumotropica was isolated from the pus swelling only and the biologic characteristic with hemolysis and Indol test (-) in some strains,was also found.The infection rate is different in each age group of the mice,which 80% in old age group,90% in 5-6 weeks and 100% in 3-4 weeks age group of the mouse.It is indicated that the young have higher sensitivity than the mature in the mice.

Abstract:This paper presents the establishment of IEA for detection of MHV,and compare the sensitivity of detection of ELISA and IEA.A total of 197 serum was analyzed.The consistent rate of the two methods was 92.5%.The results indicate that IEA is a more susceptible method as ELISA,and can test the large amount of samples with the abvantage of simplicity and rapidity.

Abstract:Hepatitis G virus was successfully transmitted to macaqucs.Five animals were inoculatcd with scrum from a paticnt whose serum was HGV RNA positive by RT PCR.The serum and bioptic liver tissues were examined by RT PCR,ELISA and light microscope respectively.The results showed that 2 macaques with normal ALT levels had seroconversion of HGV RNA and anti HGV IgG for over 50 weeks and their liver tissues had the changes of acute and chronic hepatitis which were very similar to those of patients with hepatitis G.The HGV positive serum was subpassaged in another macaque at the 7th week after transmission.The changes was as same as that of the first passage animals.

Abstract:mice of NOD inbred strain were observed for their diabetes from 3 to 52 weeks old.Total cumulative diabetes incidence in males was 28.3%,lower than that 50% in females Abrupt onset occurred among 10-33 weeks old,while male's onset was later than female's After 45 weeks old,few onset individuals could be found.The diabetic animals died within 2-5 weeks after the onset.Clinical features of the affected animals were glycosuria,hyperglycetemia,polydipsia,polyuria,polyphagia and body weight loss.Severe lymphocytic infiltration in the pancreatic islet was observed in prediabetic and diabetic animals.Insulin dependent diabetes mellitus (IDDM) of NOD mice was an autoimmune disease.NOD mice could be used as a model for human IDDM.

Abstract:This article reports how to build up the immuno depression mouse model by Dexamethasoni and apply it to test of the functionology of health care alcohol (Immunological Regulation).The results show that it is a reliable method,especially for the test of the two way immunological regulation of the health care alcohol.

Abstract:本研究将人巨细胞病毒AD169株以10^3TCID50。接种于新西兰免后，5～20d内动物死亡33．33％；将死亡动物可疑器官作病理学检查发现，早期死亡动物双肺广泛充满浆渡性渗出物，稍后死亡动物肺脏肺泡壁增厚，尘细胞增多，伴有不同程度渗出性病变，肝脏、肾脏出现灶状变性坏死灶，人巨细胞病毒抗原定位检测在上述受到损伤的组织细胞中查到HCMV特异抗原，表明人巨细胞病毒感染家兔造成的肺脏、肝脏、肾脏的严重损害，与动物死亡的关系极为密切。