Abstract:本文用抗氧化剂维生素Ｅ 预处理后，观察了三氯乙烯（３０００ｍｇｋｇ Ｂ－ Ｗ－） 一次性经口染毒２４ｈ 大鼠肝脏的超氧化物歧化酶、谷胱甘肽过氧化物酶等抗氧化酶活力及丙二醛含量的变化，结果表明三氯乙烯染毒组肝脏中丙二醛含量、超氧化物歧化酶活力及血清谷丙转氨酶、谷草转氨酶活力均高于对照组（Ｐ＜ ０－０１） ；而维生素Ｅ 干预组的丙二醛含量、超氧化物歧化酶活力及血清谷丙转氨酶、谷草转氨酶活力均分别低于三氯乙烯染毒组（Ｐ＜ ０－０１） ，说明三氯乙烯急性染毒可引起肝脏脂质过氧化反应及肝损害，肝脏超氧化物歧化酶活力升高可能是机体受自由基及脂质过氧化反应刺激而诱导产生的一种适应性反应，维生素Ｅ 对三氯乙烯所致的肝损害有一定的保护作用。

Abstract:Aim:To study the relationship between left ventricular hypertroply and blood pressure and myocardial local angiotensin II (AngII) in Spontaneosly hypertive rats(SHR). Methods:Male SHR and WKY were decapitated at 4wks, 8wks, 12wks, 24wks and 36wks. Systobic blood pressure (SBP) and left ventricle mass to body weight ratio (LVM/BW) were measured. The myocardial Ang II concentration were masured by radioimmunoassay. The liner regression between SBP, Ang II content and LVM/BW was performed. Result:Left ventricular mass positively correlated with SBP(r=0.65 P<0.05) and Ang II concentration(r-0.71 P<0.05). Conclusion: These data strongly suggested that myocardial local AngII and blood pressure may play an important role in left ventricular hypertrophy in SHR.

Abstract:以DEN与AFB诱发大鼠肝癌为模型，应用电镜酶细胞化学方法对癌周淋巴结淋巴细胞酶定位并与正常组对比酶活性变化。结果 显示：(1)ATP酶反应颗粒主要定位在质膜的内侧，G-6-P酶反应颗粒定位在内质网及线粒体等膜相结构，5′-ND反应颗粒定位在细胞膜外表面。(2)肝癌模型组ATP酶与G-6-P酶活性明显下降，5′-ND活性明显增强：(3)此结果与人肝癌癌周淋巴结淋巴细胞酶超微结构定位及活性变化结果相同。结果提示：实验性肝癌周淋巴结淋巴细胞酶活性变化可怍为研究肝癌免疫功能的客观指标。

Abstract:本文对一级、三级实验小鼠的Peyer氏斑(Peyer’s patches．PP)在数量、大小、分布、结构及功能等方面作了比较研究和分析。结果表明，一级小鼠和三级小鼠的PP在数量和大小上有显著差别。一级小鼠的PP更发达，提示PP在小鼠胃肠粘膜免疫中起着重要作用：

Abstract:In order to measure lymphocyte proliferate responses of murine thymocytes and splenocytes to ConA and LPS, MTT assay was established by optima conditions of culture time, cell concentration and amount of MTT added in experiments. MTT assay has advantages of safety, accuracy, and reliability in comparison with 3H-TdR incorporation assay, the former can be an alternate method of later one. The results of this study demonstrated that there was a significant difference of lymphocyte proliferate responses between murine strains.

Abstract:Objection To develop a animal model of human monozygotic twins. Methods C 57 BL/6J strain female mice mated with KM male mice, after seeing plug 3.5 days the compacted morulae and blastocysts were collected and bisected microsurgically by using special knife, obtained half embryos were cultured and observed. Results Take rate of bisection for morurae is 91.3%, developing rate is 57.1%, Whereas the take rate of bisection is 89.2%, the developing rate is 71.2% for blastocysts. Conclusion The F 1 demi-embryos from C 57 BL/6J and KM mice can develop in vitro after embryo bisection, the data may be useful in studying development and differentiation of monozygotic twins embryos as well as in establishing a animal model of human twins.

Abstract:Collect specimens of Twenty-four rat and mouse diets, nine rabbit diets, two dog diets and two monkey diets in China and analyze their content of moisture, ash, crude protein, crude fat and crude fiber. Only 20.8 pre cents of them are up to state standard of the rat and mouse diets. Particularly 25 pre cents in Bijing (1/4), zero in Northeast China area, North China area(0/3) and Mid-China area (0/2) 33.3 pre cents in East China (2/6), 20 pre centsin in South China (1/5), 33.3 pre cents in Southwest (1/3), 22.2 pre centsof the rabbbit diets satisfy state standard. All dog and monkey diets did not meet the demand standard.

Abstract:In this paper, we analyzed the present situation of production and supply of laboratory animals in our country, and pointed out that as the socialist market economical system was established, the production and supply of laboratory animals were bound to move toward industrialization. The route and strategy for the industrializing supply of laboratory animals were discussed.

Abstract:The hematological and biochemical parameters of 52 Beagle dogs were estimated and compared with different sexes. The result showed there were no significant differences except APTT parameters between male and female. It fundamentally accorded with that of foreign studies.

Abstract:在普通和无菌环境中，用人工饲料饲育３ 批陕２０５ ×陕２０６ 杂交蚕。２４ｈ 蚕的疏毛率，普通蚕平均９４－０％ ；无菌蚕平均９６－３ ％ 。普通蚕成活率８６－７％ 、结茧率９６－０ ％ 、平均结茧时间３１－０ 日龄、蛹化率１００ ％ ；无菌蚕成活率９６－０％ 、结茧率９８－７ ％ 、平均结茧时间３２－６ 日龄、蛹化率８８－７ ％ 。无菌蚕经检测无菌生长，可作为实验动物使用。

Abstract:A polymerase chain reaction (PCR) having high specificity and sensitivity was estibilished for detecting toxoplasma gondii (TOX) in laboratory animals, according to designing primers. The results showed that TOX might exist in rabbits (3/60) useful for teaching, which came from countryside. These findings suggest that the infection of TOX might be paid more attention in the aspect of laboratory animals. Key words TOX PCR mathematical statistics that the probability distribution of measured data obeys normal distribution. By the great difference in elastic moduli between cementum and dentin it is explained that 1 why more cementum grows at the root apexes;2 the behavior of cementum must be taken into consideration when the stress analysis for teeth is carried out.