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    • Effects of three anesthetics on electrocardiograms of male C57BL / 6 mice

      2019, 29(6):118-122.DOI: 10.3969/j. issn. 1671 -7856. 2019. 06. 019

      Keywords:mice anesthesia ethyl carbamate chloral hydrate pentobarbital sodium electrocardiogram
      Abstract (2506)HTML (0)PDF 1.45 M (3251)Favorites

      Abstract:Objective To investigate the anesthetics that do not interfere with electrocardiograms (ECG) bycomparing the effects of three anesthetics on ECG in C57BL/6 mice. Methods Mice were randomly divided into threegroups: intraperitoneal injection of 20% ethyl carbamate, 1% pentobarbital sodium, and 2. 5% chloral hydrate. Aftercomplete anesthesia, the mice were connected to an ECG scanner by a limb lead for 1 hour of electrocardiogram recording.Results Within the administration time between 0-40 min, 20% EC did not significantly affect the ECG parameters ofmice. However, mice in the 1% pentobarbital sodium group had a reduced heart rate, and prolonged PR interval and QRSduration. Mice in the 2. 5% chloral hydrate group had a reduced heart rate and prolonged PR interval. Conclusions Ourfindings indicates that 20% EC has the least effect on the ECG of C57BL/6 mice and that 2. 5% chloral hydrate is suitable for experimental studies 20 min after anesthesia is induced in mice.

    • Effectiveness of three different anesthetic techniques in intraventricular catheterization and its effect on survival rate of the rats

      2018, 28(6):89-95.DOI: 10.3969/j. issn. 1671 -7856. 2018. 06. 016

      Keywords:intraventricular catheterization chloral hydrate pentobarbital sodium isoflurane
      Abstract (2044)HTML (0)PDF 2.29 M (3190)Favorites

      Abstract:Objective To investigate the effectiveness of three different anesthetic techniques in intraventricular catheterization and its effect on the survival rate of rats. Methods Thirty Wistar rats were equally allocated into 3 groups: chloral hydrate group,pentobarbital sodium group and isoflurane group. Intraventricular catheterization was performed in the rats after anesthesia with i. p. injection of chloral hydrate and pentobarbital sodium, and isoflurane inhalation, respectively. Levels of blood glucose were detected before and at 15 and 30 minutes and 1, 3, 7, 14, 28 days after anesthesia. Body mass and 24?hour food intake were recorded before and at 1, 3, 7 days after anesthesia. The onset time and effective time of anesthesia, operation time and the survival rates on 30 days of the rats were compared and analyzed. Results The onset time and effective time of anesthesia, and the operation time in the isoflurane group were shorter than that in the chloral hydrate group, while these parameters in this group were shorter than that in the pentobarbital sodium group. Blood glucose in the chloral hydrate group was apparently increased during the surgical operation, while the body mass, 24?hour food intake and blood glucose were decreasing since one day after operation, and all the rats in this group died during the 30?day observation, mainly, due to enteroplegia. Blood glucose in the pentobarbital sodium group was mildly increased after anesthesia, while the body mass, 24?hour food intake and blood glucose were mildly decreased at one day after operation and recovered within one week. In this group, 3 rats died of respiratory distress due to overdose anesthesia and one rat died during the 30 day?observation. The blood glucose in the isoflurane group was mildly increased after operation, while the 24?hour food intake and blood glucose did not markedly changed, the body mass was stably increased, and no rat died during the 30?day?observation. Conclusions Intraperitoneal injection of chloral hydrate is not suitable for intraventricular catheterization in rats. Intraperitoneal injection of pentobarbital sodium can be only carefully applied for intraventricular catheterization under poorly?limited conditions. Isoflurane inhalation anesthesia is recommended for intraventricular catheterization in rats.

    • Anesthetic effect of sumianxin Ⅱ combined with chloral hydrate on rabbit

      2014, 24(5):15-18.DOI: 10.3969.j.issn.1671.7856.2014.005.004

      Keywords:AnesthesiaChloral hydrateSumianxin ⅡRabbit
      Abstract (2050)HTML (0)PDF 662.54 K (2472)Favorites

      Abstract:Objective To observe the anesthetic effect of Sumianxin Ⅱ combined with chloral hydrate in plastic surgical operation on rabbit and explore the fast, safe and effective anesthetic methods.Methods A total of 82 Rabbits for operation were randomly divided into A, B and C groups.The A group was injected with SumianxinⅡintramuscularly (0.35 mL/kg by weight). The B group was injected with 10% chloral hydrate intravenously (2.5~3 mL/kg by weight). The C group was injected with SumianxinⅡintramuscularly (0.2 mL/kg by weight) combined with 10% chloral hydrate intravenously(1~1.5 mL/kg by weight).The anesthetic effect of induction and recovery time of anesthesia,anesthesia maintaining time,and anesthesia mortality rate were observed and compared.Results The anesthetic effect of induction of anesthesia,recovery time of C groups fall in between which of A and B groups(P< 0.05).However, as for anesthesia maintaining time, there was no significant difference between A and C group and both the two groups were longer than B group.Conclusion SumianxinⅡcombined with chloral hydrate possess the advantages of fast anesthesia induction and recovery effect, longer anesthesia maintaining time and low mortality. Therefore it is an easy to operate, expeditious, safe and effective anesthetization for plastic surgical operation on rabbit.

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