Objective To screen obesity rat model of metabolic disturbance,and to determine whether Leptin signal transduction pathway in obesity rats are changed or not.Method Male Wistar weaning rats were divided randomly into control group and high-fat fed group.Rats of high-fat fed group were fed high-fat diet for 6 weeks,and then,screened them based on body weight gain(upper quarter for obesity-prone rats).During the dietary period,body weight and serum Leptin level of obesity-prone group rats and control group ra...